In 16th century Asia, Raphael Cain sees his wife slain and his daughter taken by supernatural villains from the underworld. He vows to pursue the demons through the centuries to kill them all and find his daughter, and with the help of a mystic, he is taught the magic—and samurai swordsmanship—it will require to accomplish this oath. His reluctant squire, Goodwin follows him through time and helps him in his quest. Now in the 21st century, Cain and Goodwin are joined by a psychologist, Sara Beckman, who studies otherworldly anomalies. Cain will need all the help he can get because now the lead demon, Mallos and his henchwoman, Vashita are gathering power and making life in the 21st century America very uncomfortable.
